A backup catcher, and two new players in Austin Meadows and Javier Baez.
With two outs and the bases loaded in the 8th inning, Cabrera singled home two runs to tie the game at 3.
Akil Baddoo tapped into a fielder's choice, sending the game into the 9th tied at 3.
But Gregory Soto gave up a moonshot to Chicago's Andrew Vaughn to give the White Sox a 4-3 lead.
Robbie Grossman struck out swinging on a 2-2 count but newcomer Austin Meadows tripled to deep right-center.
Bringing up another fresh face to Detroit in Javier Baez, who singled against the right-field wall
It was initially ruled a catch but later overturned upon review, giving the Tigers the 4-3 victory.
The ball bounced off the wall before hitting the glove of right-fielder AJ Pollock.
The weather, once again, was cold and wet but there's a lot of excitement around this Tigers team for the first time in years.
The Tigers threatened in the bottom of the sixth when Jeimer Candelario singled in Robbie Grossman from third
The Sox then brought in closer Liam Hendriks who got Baddoo to tap out.